Abstract The study of natural glycans is fundamental to modern glycomics; however, the functional analysis of these glycans is limited by their low natural abundance, structural heterogeneity, and the absence of efficient preparative-scale isolation methods.Here, we present a streamlined approach for the gram-scale production of complex natural N-g
Immune-Related Genetic Overlap Between Regional Gray Matter Reductions and Psychiatric Symptoms in Adolescents, and Gene-Set Validation in a Translational Model
Adolescence is a period of vulnerability for the maturation of gray matter (GM) and also for the onset of psychiatric disorders such as major depressive disorder (MDD), bipolar disorder and schizophrenia.Chronic neuroinflammation is considered to play a role in the etiology of these illnesses.However, the involvement of neuroinflammation in the obs
One Size Does Not Fit All: The Case for Translational Medicine
Therapy for inflammatory bowel diseases (IBD) has developed during recent years.Despite the availability of new therapeutic modalities, overall therapy success remains modest, and complete remission is usually achieved and maintained in approximately 30% of patients only.This observation can be explained by a number of reasons.First, the involvemen